Endocrine Abstracts

Introduction: Radioactive iodine (RAI) has been used to treat hyperthyroidism for over 70 years. Some centres use a fixed dose regimen while others use a calculated dose regimen. Cure rates range between 80% and 100%, with some patients requiring two or more doses. We use the fixed-dose regimen at our centre. We therefore evaluated our cure rates after a single dose of RAI to treat hyperthyroidism.Methods: We reviewed th...

Introduction: Pembrolizumab is an immune checkpoint inhibitor (ICI) used to treat advanced cancers. While improving survival rates, ICIs also cause immune-related adverse events (IRAEs). The endocrine system remains the most vulnerable to IRAEs: thyroid involvement is the commonest while pancreatic involvement is rare, affecting less than 1% of individuals. Risk factors for IRAEs include, personal or family history of autoimmune conditions, presence of another...

Introduction: Postpartum thyroiditis (PPT) occurs during the first postpartum year with a prevalence between 1.1% and 16.7%. It presents either as transient hyperthyroidism, transient hypothyroidism, or transient hyperthyroidism followed by transient hypothyroidism. Anti-thyroid peroxidase antibodies (TPOAb) levels are high in 60-85% of cases, while the less measured anti-thyroglobulin antibodies (TgAb) can also be high. Risk factors for PPT include presence o...